Our evidence is one of the reasons why we are
the preferred precision oncology partner.
With >1000 peer-reviewed publications and research abstracts, you can be confident in the science behind our tests.
to explore a selection of our pivotal studies and resources.
Gastrointestinal cancer
Targeted therapy guided by ctDNA analysis
The GOZILA Study
Nature Medicine
2024
See the studyColorectal cancer
Recurrence prediction with a tissue-free epigenomic MRD assay
COSMOS-CRC-01
Clinical Cancer Research
2024
See the studyNSCLC
Association between availability of molecular genotyping results and OS
Aggarwal et al
JCO Precision Oncology
2023
See the studyNSCLC
AI-powered PD-L1 analyser improves therapy response prediction
Choi et al
European Journal of Cancer
2022
See the studyBreast cancer
A new frontier of biomarker testing
Guardant Infinity™ Webinar
Premiered at ASCO
2024
See the webinarAll solid tumors
Quantifying ctDNA using a tissue-free test for MRD detection
Guardant Reveal™ White Paper
Sponsored by Guardant Health
2024
See the white paperWith more than 10 years of dedicated research and development, we are trusted by >15k ordering oncologists to help inform the best patient care.
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1L, first-line; CGP, comprehensive genomic profiling; ctDNA, circulating tumor DNA; mBC, metastatic breast cancer; MRD, minimal residual disease; OS, overall survival; PD-L1, programmed death-ligand 1; SOC, standard of care.
References: 1. Parikh A, Van Seventer E, Siravegna G, et al. Minimal residual disease detection using a plasma-only circulating tumor DNA assay in patients with colorectal cancer. Clin Cancer Res. 2021;27(20):5586-5594. doi:10.1158/1078-0432.CCR-21-0410 2. Janni W, Friedl T, Rack B, et al. Analysis of ctDNA for the detection of minimal residual disease (MRD) using a tissue-free, multiomic assay in patients with early-stage breast cancer. Poster presented at: San Antonio Breast Cancer Symposium; December 5-9, 2023; San Antonio, TX. Accessed October 8, 2024. doi:10.1158/1538-7445.SABCS23-PS06-06 3. Nakamura Y, Tsukada Y, Matsuhashi N, et al. Colorectal cancer recurrence prediction using a tissue-free epigenomic minimal residual disease assay. Clin Cancer Res. 2024;30(19):4377-4387. doi:10.1158/1078-0432.CCR-24-1651 4. Zhang Q, Luo J, Wu S, et al. Prognostic and predictive impact of circulating tumor DNA in patients with advanced cancers treated with immune checkpoint blockade. Cancer Discov. 2020;10(12):1842-1853. doi:10.1158/2159-8290.CD-20-0047 5. Thompson JC, Carpenter EL, Silva BA, et al. Serial monitoring of circulating tumor DNA by next-generation gene sequencing as a biomarker of response and survival in patients with advanced NSCLC receiving pembrolizumab-based therapy. JCO Precis Oncol. 2021;5:510-524. doi:10.1200/PO.20.00321 6. Aggarwal C, Thompson JC, Black TA, et al. Clinical implications of plasma-based genotyping with the delivery of personalized therapy in metastatic non–small cell lung cancer. JAMA Oncol. 2019;5(2):173-180. doi:10.1001/jamaoncol.2018.4305 7. Leighl NB, Page RD, Raymond VM, et al. Clinical utility of comprehensive cell-free DNA analysis to identify genomic biomarkers in patients with newly diagnosed metastatic non-small cell lung cancer. Clin Cancer Res. 2019;25(15):4691-4700. doi:10.1158/1078-0432.CCR-19-0624 8. Choi S, Cho SI, Ma M, et al. Artificial intelligence–powered programmed death ligand 1 analyser reduces interobserver variation in tumour proportion score for non–small cell lung cancer with better prediction of immunotherapy response. Eur J Cancer. 2022;170:17-26. doi:10.1016/j.ejca.2022.04.011 9. Cui W, Milner-Watts C, O’Sullivan H, et al. Up-front cell-free DNA next generation sequencing improves target identification in UK first line advanced non-small cell lung cancer (NSCLC) patients. Eur J Cancer. 2022;171:44-54. doi:10.1016/j.ejca.2022.05.012 10. Page RD, Drusbosky LM, Dada H, et al. Clinical outcomes for plasma-based comprehensive genomic profiling versus standard-of-care tissue testing in advanced non–small cell lung cancer. Clin Lung Cancer. 2022;23(1):72-81. doi:10.1016/j.cllc.2021.10.001 11. Aggarwal C, Marmarelis ME, Hwang WT, et al. Association between availability of molecular genotyping results and overall survival in patients with advanced nonsquamous non–small-cell lung cancer. JCO Precis Oncol. 2023;7:e2300191. doi:10.1200/PO.23.00191 12. Nakamura Y, Ozaki H, Ueno M, et al. Targeted therapy guided by circulating tumor DNA analysis in advanced gastrointestinal tumors. Nat Med. 2024. doi:10.1038/s41591-024-03244-8 13. Harvey-Jones E, Raghunandan M, Robbez-Masson L, et al. Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer. Ann Oncol. 2024;35(4):364-380. doi:10.1016/j.annonc.2024.01.003